Cadenza CD-C18 - 독특한 엔드캡핑을 통한 고성능 ODS 컬럼 > 제품소개 | imtakt korea

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Cadenza CD-C18

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Cadenza

Cadenza CD-C18 - 독특한 엔드캡핑을 통한 고성능 ODS 컬럼

Features

● 세계 최고 수준의 이론단수 컬럼 : 50,000 Plates (250 × 4.6 mm)

● 탁월한 분리 성능 : 유사체 (analogs) 및 이성질체 (isomers)의 고분리 가능

● 독자적 엔드캡핑 기술 : 산·염기·알칼리 조건에서도 뛰어난 내구성

● 다양한 컬럼 사이즈 : 내경 (ID) 0.075 ~ 28 mm / 길이 10 ~ 500 mm

● 고압 조건 지원 : HP / UP 옵션 제공

● 금속-프리 컬럼 (Metal-Free, MF)

SPECIFICATIONS

Main Specifications

Particle size	3 μm (Cadenza CD-C18) 5 μm (Cadenza 5CD-C18)
Base materials	완전다공성 고순도 실리카겔 (Fully porous, high-purity silica gel)
Pore size	12 nm
Ligand	옥타데실기 (Octadecyl group)
End-capping	메틸기, 폴리머릭 엔드캡핑 (Methyl group, polymeric end-capping)
Target molecular weight	10 kDa 이하
pH range	pH 1.5 - 9
Maximum pressure	250 bar / 3,500 psi / 25 MPa HP: 500 bar / 7,500 psi / 50 MPa UP: 1,000 bar / 15,000 psi / 100 MPa
USP Code	L1

3 μm 컬럼 시장을 이끌어 온 IMTAKT의 대표 제품

2000년 출시 이래, Cadenza CD-C18은 3 μm 입자 컬럼 시장을 선도해 온 IMTAKT의 대표 제품입니다. 현재 전 세계 40개국 이상에서 사용되며, IMTAKT를 대표하는 플래그십 컬럼으로 자리매김하고 있습니다.

세계 최고 수준의 이론단수

Cadenza CD-C18은 낮은 압력에서도 높은 이론단수를 구현하는 독보적인 성능을 자랑합니다. 250 x 4.6mm 규격에서 50,000 plates에 달하는 수치는, 3 μm 입자 컬럼으로서는 여전히 세계 최고 수준의 기록입니다.

Super Column Technology

이러한 성과의 배경에는 IMTAKT만의 Super Column Technology가 있습니다.

●2 μm 비다공성 실리카 생산을 통해 축적한 미세입자 컬럼 기술
●새롭게 개발된 고정상에 기반한 혁신적인 표면 구조 설계
●재현성이 뛰어난 신규 컬럼 제조 기술의 개발

Cadenza CD-C18은 단순한 제품을 넘어, IMTAKT의 개발 철학과 기술력이 집약된 결과물입니다. 그 철학과 기술은 지금도 후속 제품군에 고스란히 이어지고 있으며, 연구자들의 신뢰와 선택을 통해 그 가치를 증명하고 있습니다.

대표 적용 사례 (Notable Applications)

그 외 더 많은 적용 사례는 애플리케이션 검색에서 확인하실 수 있습니다.

기술 자료 (Technical Information)

Cadenza CD-C18의 특징

Cadenza CD-C18과 Unison UK-C18의 차이

애플리케이션 (Applications)

Cadenza CD-C18 애플리케이션 전체보기 →

최신 애플리케이션

유저 리포트 (User Reports)

●Harvard Medical School, USA
High-resolution LC—MS/MS untargeted "Lipidomics" approach applicable to a wide range of biological samples Comment in the paper: "Cadenza CD-C18 excels in robustness, reproducibility, and longevity."
●IONICS Mass Spectrometry (PerkinElmer) USA
Reproducibility of 5000 analyses of testosterone and 17—hydroxyprogesterone using IONICS BO 220 High-throughput parallel analysis of immunosuppressants in whole blood using a coaxial flow ion source LC-MS/MS system with ESI/ESI dual probes Rapid and simple LC—MS/MS analysis of pain relievers in urine Highly sensitive LC-MS/MS analysis of 25-hydroxyvitamin D3 in serum using offline pretreatment with a multi-mode ODS stationary phase evaluation test mix
●SCIEX, USA
Rapid Identification of Metabolites Using MetabolitePilot Software and the Triple TOF 5600 System Identification of Reactive Metabolites by High-throughput Scanning Linear Ion Trap
●Huntingdon Life Sciences, USA
Plasma Cholesterol Analysis Concerning Ion Suppression in LC-MS
●Tsuno Food Industrial Co., Ltd.
Comprehensive Analysis of Functional Components in Rice Bran Oil
●Tokushima Bunri University
Molecular Species Identification of Sphingomyelin by LC-MS/MS
●Shionogi & Co., Ltd.
Ultra-Fast Quantitative Analysis of Drugs in Plasma by LC-MS/MS
●Yamaguchi Environmental Health Center
Residual Pesticide Testing by LC-MS/MS
●Shimadzu Corporation
Analysis of Proteins and Peptides by LC-MS Analysis of Aflatoxins by LC-MS
●Wakayama Pharmaceutical Association
Pesticide Analysis by LC-MS/MS
●Takara Bio Inc.
Remarkable Differences in Column Injection Volume

유저 논문·학술 자료 (User Articles)

Linezolid (Oxazolidinone class antibiotic)

Population pharmacokinetics and pharmacodynamics of linezolid-induced thrombocytopenia in hospitalized patients
Yasuhiro Tsuji, Nicholas H.G. Holford, Hidefumi Kasai, Chika Ogami, Young-A Heo, Yoshitsugu Higashi, Akiko Mizoguchi, Hideto To and Yoshihiro Yamamoto
Toyama University / UNIVERSITY OF AUCKLAND (New Zealand) / Sasebo Chuo Hospital
British Journal of Clinical Pharmacology, 83, 1758-1772 (2017)

Lipidomics

A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source
Susanne B. Breitkopf, Stephane J. H. Ricoult, Min Yuan, Ying Xu, David A. Peake, Brendan D. Manning, John M. Asara
Harvard University, HARVARD MEDICAL SCHOOL (USA)
Metabolomics, 2017 Mar;13(3):30. doi: 10.1007/s11306-016-1157-8

Plant Hormone-like Substances (Jasmonic Acid, Salicylic Acid, Abscisic Acid)

Comparative de novo transcriptome profiles in Asparagus officinalis and A. kiusianus during the early stage of Phomopsis asparagi infection
Mostafa Abdelrahman, Naoyuki Suzumura, Mai Mitoma, Satoshi Matsuo, Takao Ikeuchi, Mitsutaka Mori, Kyoko Murakami, Yukio Ozaki, Masaru Matsumoto, Atsuko Uragami & Akira Kanno
Tohoku University / ASWAN UNIVERSITY (Egypt) / National Agriculture and Food Research Organization (NARO) / Kagawa Prefectural Agricultural Experiment Station / Kyushu University
Scientific Reports, 2017, 7: 2608. DOI: 10.1038/s41598-017-02566-7

β-Carotene Oxygenase Inhibitors, Retinoids (Fenretinide)

Inhibitory effects of fenretinide metabolites N-[4-methoxyphenyl]retinamide (MPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (3-keto-HPR) on fenretinide molecular targets β-carotene oxygenase 1, stearoyl-CoA desaturase 1 and dihydroceramide Δ4-desaturase 1
Eugenia Poliakov, William Samuel, Todd Duncan, Danielle B. Gutierrez, Nathan L. Mata, T. Michael Redmond
NATIONAL INSTITUTE OF HEALTH (NIH), ACUCELA INC. (USA)
PLOS ONE - https://doi.org/10.1371/journal.pone.0176487 April 27, 2017

Ginsenoside

Photoprotective effects of topical ginseng leaf extract using Ultraflo L against UVB-induced skin damage in hairless mice
Yang Hee Hong, Hyun-Sun Lee, Eun Young Jung, Sung-Hee Han, Yooheon Park, Hyung Joo Suh
SUWON WOMEN’S UNIVERSITY, AGENCY FOR KOREA NATIONAL FOOD CLUSTER, JEONJU UNIVERSITY, KOREA UNIVERSITY, DONGGUK UNIVERSITY RESEARCH INSTITUTE (Korea)
J Ginseng Res., 41(4), 456-462 (2017)

Ochratoxin A

Lack of an Apparent Association between Mycotoxin Concentrations in Red Chili Peppers and Incidence of Gallbladder Cancer in India: An Ecological Study
Toshikazu Ikoma, Vinay Kumar Kapoor, Anu Behari, Kumudesh Mishra, Yasuo Tsuchiya, Takao Asai, Kazuo Endoh, Kiyoshi Okano, Kazutoshi Nakamura
Hokuriku University / Niigata University / Niigata University of Health and Welfare / Mycotoxin Inspection Association / Sanjay Gandhi Post Graduate Institute of Medical Sciences (India)
Asian Pac J Cancer Prev, 17 (7), 3499-3503 (2016)

Advanced Glycation Endproducts (AGEs)

Cleaving effect of pomegranate (Punica granatum) extract on crosslink derived from advanced glycation endproducts
Masayuki Yagi, Riko Mitsuhashi, Ai Watanabe, Yu Moritani, Junko Naito, Parengkuan Lanny, Hideyuki Ito, Akifumi Nagatomo, Norihisa Nishida, Yoshikazu Yonei
Doshisha University / Okayama Prefectural University
Glycative Stress Research, 2 (2), 58-66 (2015)

Polyphenols (Antioxidants)

ANTIOXIDANT ACTIVITY OF RYE BREAD ENRICHED WITH MILLED BUCKWHEAT GROATS FRACTIONS
Miroslaw Zmijewski, Anna Sokol-Letowska, Ewa Pejcz, Dagmara Orzel
WROCLAW UNIVERSITY (Poland)
Rocz Panstw Zakl Hig, 66(2), 115-121 (2015)

Designated Substances and Pharmaceutical Ingredients in Health Foods

LC-MS/MS による指定薬物等のスペクトルライブラリー作成
多田裕之，神山恵理奈，吉田一郎，南谷臣昭，河村博，坂井至通
岐阜県保健環境研究所
岐阜県保健環境研究所報, 第19号, 11-16 (2011)

Phenol

要監視項目フェノールの測定について
大野ちづ子
徳島県保健環境センター
全国環境研会誌, 35, 4, 7-13 (2010)

Veterinary Drugs

LC/MS/MSを用いた畜産食品中のサルファ剤の一斉分析
浦西克維, 山下浩一, 山本圭吾
奈良県保健環境研究センター
奈良県保健環境研究センター年報, 第45号, 62-64 (2010)

Estradiol (E2), Dihydrotestosterone (DHT), Testosterone, Androstenedione

Increased intratumoral androgens in human breast carcinoma following aromatase inhibitor exemestane treatment
Kiyoshi Takagi, Yasuhiro Miki, Shuji Nagasaki, Hisashi Hirakawa, Yoshiaki Onodera, Jun-ichi Akahira, Takanori Ishida, Mika Watanabe, Izo Kimijima, Shin-ichi Hayashi, Hironobu Sasano, Takashi Suzuki
Tohoku University / Tohoku Kosai Hospital / Tohoku University Hospital / North Fukushima Medical Center
Endocrine-Related Cancer, 17, 415-430 (2010)

Bisacodyl, Hydrochlorothiazide, Fluoxetine, Diazepam, Phentermine

いわゆる「ホスピタルダイエット」類似製品におけるGC-MS法及びLC-MS-MS法を用いた含有医薬品成分の分析
熊坂謙一, 宮澤眞紀, 松阪綾子, 麻生順子, 小島尚
神奈川県衛生研究所
CHROMATOGRAPHY, Vol.31, No.2, 77-86 (2010)

Proteomics

A new possible lung cancer marker: VGF detection from the conditioned medium of pulmonary large cell neuroendocrine carcinoma-derived cells using secretome analysis
Toshihide Matsumoto, Yusuke Kawashima, Ryo Nagashio, Taihei Kageyama, Yoshio Kodera, Shi-Xu Jiang, Isao Okayasu, Toru Kameya, Yuichi Sato
Kitasato University / National Cancer Center / Shizuoka Cancer Center
The International Journal of Biological Markers, Vol. 24 no. 4, pp. 282-285 (2009)

Curcumin Glycoside

Functional and Structural Characterization of a Flavonoid Glucoside 1,6-Glucosyltransferase from Catharanthus roseus
Sayaka Masada, Kazuyoshi Terasaka, Yukie Oguchi, Seiji Okazaki, Tunehiro Mizushima, Hajime Mizukami
Nagoya City University / Nagoya University
Plant Cell Physiol. 50 (8): 1401-1415 (2009)

TPN-Related Drugs, Chemotherapy-Related Drugs

注射薬混合時に用いる各種シリンジフィルターへの薬物吸着に関する検討
石川朋樹，杉山恵理花，佐藤均
昭和大学
医療薬学, 35 (3) 189-194 (2009)

CLE44 Peptide

Identification of a biologically active, small, secreted peptide in Arabidopsis by in silico gene screening, followed by in silico LC-MS-based structure analysis
Kentaro Ohyama, Mari Ogawa, Yoshikatsu Matsubayashi
Nagoya University
The Plant Journal, 55, 152-160 (2008) <br>
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-313X.2008.03464.x

Positive List

高速液体クロマトグラフィー/タンデム質量分析法による畜水産物中動物用医薬品スクリーニング分析法
甲斐茂美, 赤星猛, 藤巻照久, 伊藤伸一, 金澤秀子
神奈川県衛生研究所 / 共立薬科大学
分析化学, 56 (12), 1105-1113 (2007)

Residual Pesticides

LC/MS/MSによる果実・野菜中のジクロルボス，トリクロルホンおよびナレドの同時分析
伊吹幸代, 浦西克維, 宇野正清
奈良県保健環境研究センター
食品衛生学雑誌, 48巻 5号, 139-143 (2007)

Soy Isoflavones

Bioavailability of Isoflavones after Ingestion of Soy Beverages in Healthy Adults
Mitsuyoshi Kano, Tomomi Takayanagi, Katsuhisa Harada, Seigo Sawada, and Fumiyasu Ishikawa
Yakult
The Journal of Nutrition, 136, 9, 2291-2296 (2006)

Phosphorylated Peptides

Self-activation of Serine/Threonine Kinase AfsK on Autophosphorylation at Threonine-168
Ayami Tomono, Mari Mashiko, Tadahiro Shimazu, Hirotaka Inoue, Hiromichi Nagasawa, Minoru Yoshida, Yasuo Ohnishi, Sueharu Horinouchi
The University of Tokyo
J. Antibiot. 59(2), 117-123 (2006)

202 Pesticides

ポジティブリスト制度施行後の山口県における残留農薬検査状況について
立野幸治, 藤原美智子, 津田元彦, 三浦泉
山口県環境保健センター
山口県環境保健センター所報, 第49号, 43-51 (2006)

Anionic Surfactants

化学物質環境実態調査におけるLC/MSを用いた化学物質の分析法とその解説
環境水・底質中の直鎖アルキルベンゼンスルホン酸ナトリウム（LAS）の分析
古武家善成
兵庫県立健康環境科学研究センター / 環境省
https://www.env.go.jp/chemi/anzen/lcms_method/index.html (2006)

Indole-3-Acetic Acid

Metabolic Profiling of Tryptophan-overproducing Rice Calli that Express a Feedback-insensitive α Subunit of Anthranilate Synthase
Keiko Morino, Fumio Matsuda, Haruna Miyazawa, Akiko Sukegawa, Hisashi Miyagawa, Kyo Wakasa
Kyoto University / Japan Science and Technology Agency / National Institute of Crop Science
Plant Cell Physiol., 46(3), 514-521 (2005)

Neocarzinostatin (Antibiotic)

The Neocarzinostatin Biosynthetic Gene Cluster from Streptomyces carzinostaticus ATCC 15944 Involving Two Iterative Type I Polyketide Synthases
Wen Liu, Koichi Nonaka, Liping Nie, Jian Zhang, Steven D. Christenson, Juyun Bae, Steven G. Van Lanen, Emmanuel Zazopoulos, Chris M. Farnet, Catherine F. Yang, Ben Shen
University of Wisconsin-Madison (USA) / Ecopia Biosciences Inc. (Canada) / Rowan University (USA)
Chemistry & Biology, 12, 293-302 (2005)

Trichothecene Mycotoxins (HT-2 Toxin, T-2 Toxin, Diacetoxyscirpenol, Neosolaniol, Deoxynivalenol, Nivalenol, Fusarenon X, 3-Acetyl Deoxynivalenol, 15-Acetyl Deoxynivalenol)

LC/MS/MSによる麦茶およびビール中のトリコテセン系カビ毒の分析
須賀啓子, 望月直樹, 原山耕一, 山下博
アサヒビール
食品衛生学雑誌, 45, 6, 307-312 (2004)

Residual Veterinary Drugs

LC/MSによる豚筋肉および肝臓中のカルバドックス代謝体(キノキサリン-2-カルボン酸およびデスオキシカルバドックス)の定量
堀江正一, 村山三徳
埼玉県衛生研究所 / 国立医薬品食品衛生研究所
食品衛生学雑誌, 45, 3, 135-140 (2004)

Benzophenone Metabolites

Estrogenicity of Metabolites of Benzophenone Derivatives Examined by a Yeast Two-Hybrid Assay
Satoshi Takatori, Yoko Kitagawa, Hajime Oda, Gunpei Miwa, Jun-ichi Nishikawa, Tsutomu Nishihara, Hiroyuki Nakazawa, Shinjiro Hori
Osaka Prefectural Institute of Public Health / Osaka University / Hoshi University
Journal of Health Science, 49 (2), 91-98 (2003)

Anthocyanins

Simple and Rapid Spectrophotometric Method for Selecting Purple-Fleshed Sweet Potato Cultivars with High Radical-Scavenging Activity
Tomoyuki Oki, Miyuki Osame, Mami Masuda, Mio Kobayashi, Shu Furuta, Yoichi Nishiba, Toru Kumagai, Tetsuo Sato, Ikuo Suda
Kyushu Okinawa Agricultural Research Center
Breeding Science, 53, 2, 101-107 (2003)

Nitro-p-Coumaric Acid

Enzymatic Nitration of Phytophenolics: Evidence for Peroxynitrite-independent Nitration of Plant Secondary Metabolites
Yasuko Sakihama, Ryoko Tamaki, Hisashi Shimoji, Toshio Ichiba, Yukiharu Fukushi, Satoshi Tahara, Hideo Yamasaki
University of the Ryukyus / Hokkaido University / Okinawa Prefectural Industrial Technology Center
FEBS Letters, 553, 377-380 (2003)

Peptide Library

Construction of a Protein-Detection System Using a Loop Peptide Library with a Fluorescence Label
Mizuki Takahashi, Kiyoshi Nokihara, and Hisakazu Mihara
Tokyo Institute of Technology / HiPep Research Institute
Chemistry & Biology, Vol. 10, Pages 53-60 (2003)

Volicitin (Insect Saliva Component, Linolenic Acid Derivative)

Identification of Volicitin-related Compounds from the Regurgitant of Lepidopteran Caterpillars
Naoki Mori, Naoko Yoshinaga, Yoshitsugu Sawada, Masao Fukui, Masami Shimoda, Kenji Fujisaki, Ritsuo Nishida & Yasumasa Kuwahara
Kyoto University / National Institute of Agrobiological Sciences
Biosci. Biotechnol. Biochem., Vol. 67, Issue 5, Pages 1168-1171 (2003)

Photo-Induced Peptide Cleavage (Green Fluorescent Protein)

Photo-Induced Peptide Cleavage in the Green-to-Red Conversion of a Fluorescent Protein
Hideaki Mizuno, Tapas Kumar Mal, Kit I. Tong, Ryoko Ando, Toshiaki Furuta, Mitsuhiko Ikura, and Atsushi Miyawaki
RIKEN / University of Toronto (Canada) / Toho University
Molecular Cell, Vol. 12, Pages 1051-1058 (2003)

Alzheimer's Drug

A Novel β-Sheet Breaker, RS-0406, Reverses Amyloid β-Induced Cytotoxicity and Impairment of Long-Term Potentiation in Vitro
Yasuhiro Nakagami, Satoko Nishimura, Takako Murasugi, Isao Kaneko, Masaki Meguro, Shinji Marumoto, Hiroshi Kogen, Kazuo Koyama & Tomiichiro Oda
Sankyo
Journal of Pharmacology, Vol. 137, Pages 676-682 (2002)

Isoflavone

北海道産大豆及び大豆加工食品中のイソフラボン含有量について
高橋哲夫, 斉藤明子, 橋本諭. 佐藤千鶴子
北海道立衛生研究所報, 52, 29-36 (2002)

Aflatoxin

厚生労働省通知アフラトキシン試験法の複数機関による評価研究
穐山浩, 田中敏嗣, 中島正博, 藤田和弘, 里山俊哉, 三浦嘉巳, 米谷民雄
国立医薬品食品衛生研究所 / 神戸市環境保健研究所 / 名古屋市衛生研究所 / 日本食品分析センター
日本食品化学学会誌, Vol 9 (3), 120-124 (2002)

DD- / DL-Peptide

A Novel α-Amino-Acid Esterase from Bacillus Mycoides Capable of Forming Peptides of DD- and DL-Configurations
Akio Sugihara, Yuji Shimada, Shigeo Sugihara, Toshihiro Nagao, Yomi Watanabe, Yoshio Tominaga
Osaka Municipal Technical Research Institute / Tokushima Bunri University
J. Biochem., Vol. 130, Pages 119-126 (2001)