Products

scroll down
Unison UK-C18 - 수계 100%에서 비수계까지 분리 가능한 고분리능 ODS 컬럼

Unison

<span class="featureDot">●</span> 250 × 4.6 mm 규격에서 세계 최고 50,000 plates 이론단수 달성

<span class="featureDot">●</span> 100% 수성부터 비수성 이동상까지 폭넓은 선택성 제공

<span class="featureDot">●</span> 독자적 엔드캡핑으로 산·염기·알칼리 내성 우수

<span class="featureDot">●</span> 다양한 컬럼 사이즈 지원 : 내경(ID) 0.075 ~ 28 mm / 길이 10 ~ 500 mm

<span class="featureDot">●</span> 고압 사양 옵션 : HP / UP 옵션 제공

<span class="featureDot">●</span> 고압 메탈-프리 컬럼 (MF, 50 MPa) 지원

Unison UK-C18 - 수계 100%에서 비수계까지 분리 가능한 고분리능 ODS 컬럼

Features

 250 × 4.6 mm 규격에서 세계 최고 50,000 plates 이론단수 달성

 100% 수성부터 비수성 이동상까지 폭넓은 선택성 제공

 독자적 엔드캡핑으로 산·염기·알칼리 내성 우수

 다양한 컬럼 사이즈 지원 : 내경(ID) 0.075 ~ 28 mm / 길이 10 ~ 500 mm

 고압 사양 옵션 : HP / UP 옵션 제공

 고압 메탈-프리 컬럼 (MF, 50 MPa) 지원

SPECIFICATIONS

Main Specifications

Particle size

3 μm (Unison UK-C18)

5 μm (Unison US-C18)

Base materials 완전다공성 고순도 실리카겔 (Fully porous, high-purity silica gel)
Pore size 13 nm
Ligand 옥타데실기 (Octadecyl group)
End-capping 있음 (고분자 엔드캡핑, Polymeric end-capping)
Target molecular weight 10 kDa 이하
pH range pH 1.5 - 9
Maximum pressure

250 bar / 3,500 psi / 25 MPa

HP: 500 bar / 7,500 psi / 50 MPa

UP: 1,000 bar / 15,000 psi / 100 MPa

USP Code L1

고해상도·고속 3 μm ODS 컬럼

Unison UK-C18는 Cadenza CD-C18의 성능을 계승한 고해상도·고속 3 μm ODS 컬럼으로, 기존 5 μm 컬럼 대비 빠른 분석 속도와 뛰어난 분리 성능을 제공합니다.

100% 수성부터 저극성까지, 폭넓은 선택성

100% 수성 이동상에서도 안정적인 극성 화합물 분리가 가능하며, 저극성 화합물의 용출 특성도 우수해 폭넓은 극성 범위 분석에 최적입니다.

약전 규격에도 대응하는 5 μm 버전

Unison US-C18는 UK-C18 (3 μm)과 동일한 표면 구조를 가진 저압용 5 μm 컬럼으로, 약전 규격 분석에도 적합한 고성능 ODS 컬럼입니다.

Low Carryover (낮은 캐리오버)

Unison UK-C18은 의약품 LC-MS 분석에서 우수한 낮은 캐리오버 성능을 보여줍니다. 이는 기존 충진제 합성법과는 다른 방식의 개발과, 새로운 고분자 엔드캡핑 기술 덕분인 것으로 알려져 있습니다.

참고문헌:
Universal LC-MS Method for Minimized Carryover in a Discovery Bioanalytical Setting
John S. Williams, Stephanie H. Donahue, Hong Gao, Christopher L. Brummel
Bioanalysis (2012) 4(9), 1025-1037

관련 애플리케이션 검색 (실시간 연동)

Unison UK-C18으로 진행된 모든 애플리케이션 데이터와 유저 리포트를 실시간으로 검색할 수 있습니다. (영문 사이트와 동일한 데이터베이스를 사용하여 새로운 자료가 등록되는 즉시 반영됩니다.)

Unison UK-C18 애플리케이션 전체보기 →

애플리케이션 (Applications)

최신 애플리케이션

유저 리포트 (User Reports)

유저 논문·학술 자료 (User Articles)

Anti-SARS-CoV-2 (COVID-19) Drugs

3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents
Sho Konno, Kiyotaka Kobayashi, Miki Senda, Yuta Funai, Yuta Seki, Ikumi Tamai, Laura Schäkel, Kyousuke Sakata, Thanigaimalai Pillaiyar, Akihiro Taguchi, Atsuhiko Taniguchi, Michael Gütschow, Christa E. Müller, Koh Takeuchi, Mikako Hirohama, Atsushi Kawaguchi, Masaki Kojima, Toshiya Senda, Yoshiyuki Shirasaka, Wataru Kamitani, and Yoshio Hayashi
The University of Tokyo / Kanazawa University / High Energy Accelerator Research Organization / UNIV.BONN (GERMANY) / UNIV.TUBINGEN (GERMANY) / National Institute of Advanced Industrial Science and Technology / University of Tsukuba / Gunma University
Journal of Medicinal Chemistry 2022 65 (4), 2926-2939


Polyphenols

The Contents of Polyphenols in Perilla frutescens (L.) Britton var. frutescens (Egoma) Leaves are Determined by Vegetative Stage, Spatial Leaf Position, and Timing of Harvesting during the Day
Yuba Raj Gaihre, Keisuke Tsuge, Hiroshi Hamajima, Yasuo Nagata, and Teruyoshi Yanagita
Saga Industrial Promotion Organization / Industrial Technology Center of Saga / Nagasaki University
Journal of Oleo Science,70, 6, 855-859, 2021


Diacylglycerol

Diacylglycerol kinase d and sphingomyelin synthase.related protein functionally interact via their sterile a motif domains
Chiaki Murakami, Fumi Hoshino, Hiromichi Sakai, Yasuhiro Hayashi, Atsushi Yamashita and Fumio Sakane
Chiba University / Shimane University / Teikyo University
J. Biol. Chem. (2020) 295(10) 2932-2947


N-Nitrosodimethylamine Impurity

Rapid and efficient high performance liquid chromatography analysis of N-nitrosodimethylamine impurity in valsartan drug substance and its products
Sayaka Masada, Genichiro Tsuji, Ryoko Arai, Nahoko Uchiyama, Yosuke Demizu, Tomoaki Tsutsumi, Yasuhiro Abe, Hiroshi Akiyama, Takashi Hakamatsuka, Ken-ichi Izutsu, Yukihiro Goda & Haruhiro Okuda
National Institute of Health Sciences
SCIENTIFIC REPORTS/NATURE RESEARCH, (2019) 9:11852


Oligopeptides

Mass spectrometry enumeration of filamentous M13 bacteriophage
Author links open overlay panel Tingting Wang, Ai Nguyen, Linwen Zhang, Illarion V. Turko
NIST (USA)
Analytical Biochemistry, Volume 582, 1 October 2019, 113354


PNP-Isomaltooligosaccharides

Engineered dextranase from Streptococcus mutans enhances the production of longer isomaltooligosaccharides
Patcharapa Klahan, Masayuki Okuyama, Kohei Jinnai, Min Ma, Asako Kikuchi, Yuya Kumagai, Takayoshi Tagami & Atsuo Kimura
Hokkaido University
BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, 2018, VOL. 82, NO. 9, 1480-1487


Advanced Glycation End Products (AGEs)

Measurement of pentosidine in human plasma by high performance liquid chromatography
Masayuki Yagi, Kana Isshiki, Wakako Takabe, Kaori Ishizaki, Yoshikazu Yonei
Doshisha University
Glycative Stress Research 2018; 5 (2): 119- 128


Bisphenol A Conjugates (Glucuronide Conjugate, Sulfate Conjugate)

Bisphenol A glucuronide/sulfate diconjugate in perfused liver of rats
Hiroki INOUE, Shino KEMANAI, Chie SANO, Seiyu KATO, Hiroshi YOKOTA and Hidetomo IWANO
Rakuno Gakuen University
J Vet Med Sci. 2016 May; 78(5): 733-737


Affinity Selection-Mass Spectrometry (AS-MS)

Characterization of Kinetic Binding Properties of Unlabeled Ligands via a Preincubation Endpoint Binding Approach
Yuji Shimizu, Kazumasa Ogawa, and Masaharu Nakayama
Takeda Pharmaceutical Company Limited
Journal of Biomolecular Screening, 2016, Vol. 21(7) 729-737


Anti-Allergy Drugs

乾燥ろ紙を用いた母乳中の抗アレルギー薬 セチリジン レボセチリジン 測定系確立
齊藤 順平, 八鍬 奈穂, 鈴木 朋, 中島 研, 村島 温子, 左合 治彦, 石川 洋一
国立成育医療研究センター
医療薬学 42(10) 661-669 (2016)


Cyanogenic Glycosides

The Acute Encephalopathy Induced by Intake of Sugihiratake Mushroom in the Patients with Renal Damage Might Be Associated with the Intoxication of Cyanide and Thiocyanate
Hiroshi Akiyama, Hideki Matsuoka, Takanori Okuyama, Kyohei Higashi, Toshihiko Toida, Hiroyuki Komatsu, Yoshiko Sugita-Konishi, Satomi Kobori, Yukio Kodama, Midori Yoshida, Hitoshi Endou
National Institute of Health Sciences / Chiba University / Shimik BioResearch Center / Kitasato University
Food Safety, Volume 3 Issue 1 Pages 16-29 (2015)


Trace Impurities (Azorubine)

赤色102号中に微量存在するアゾ化合物の構造解析
合田麻美, 堀川 学, 岩下 孝, 澤田 元充, 塚嵜 大輔, 橘 津義, 菅根 克己, 原田 雅己
サントリー / 港区みなと保健所
食品衛生学雑誌, 54巻 (2013) 3号, 188-197


Lysosome Gb3 (Lyso-Gb3, Fabry Disease)

Screening of Male Dialysis Patients for Fabry Disease by Plasma Globotriaosylsphingosine
Hiroki Maruyama, Takuma Takata, Yutaka Tsubata, Ryushi Tazawa, Kiyoe Goto, Jun Tohyama, Ichiei Narita, Hidekatsu Yoshioka, and Satoshi Ishii
Niigata University / Nagaoka Chuo General Hospital / Niigata Prefectural Central Hospital / Niigata University Medical and Dental Hospital / Oita University
Clin. J. Am. Soc. Nephrol., 8:629-636, April, 2013


Ascorbic Acid (Dehydroascorbic Acid)

ODS系カラムによるビタミンCの高速液体クロマトグラフィー分析
永田 雅靖
農業・食品産業技術総合研究機構 野菜茶業研究所
日本食品科学工学会誌 60(2), 96-99, 2013


Narcotics

LC-MS/MS analysis of tetrahydrocannabinol (THC) and its metabolite (Carboxy-THC) in whole blood
Solid-Phase Extraction and Analysis of THC and Carboxy-THC from Whole Blood Using a Novel Fluorinated Solid-Phase Extraction Sorbent and Fast Liquid Chromatography-Tandem Mass Spectrometry
Albert A. Elian and Jeffery Hackett
Massachusetts Police State Crime Laboratory / Northern Tier Research (USA)
Journal of Analytical Toxicology, Vol. 33, October 2009, pp461-469 J Forensic Toxicol Pharmacol 2012, 1:1


Gangliosides

Lyso-GM2 Ganglioside: A Possible Biomarker of Tay-Sachs Disease and Sandhoff Disease
Takashi Kodama, Tadayasu Togawa, Takahiro Tsukimura, Ikuo Kawashima, Kazuhiko Matsuoka, Keisuke Kitakaze, Daisuke Tsuji, Kohji Itoh, Yo-ichi Ishida, Minoru Suzuki, Toshihiro Suzuki, Hitoshi Sakuraba
Meiji Pharmaceutical University / Tokyo Metropolitan Institute of Medical Science / Tokushima University / RIKEN
PLoS ONE, December 2011, Volume 6, Issue 12, e29074


Daizein, Genistein, Glycitein, Daidzin, Genistin, Glycitin

食品中の健康機能性成分の分析法マニュアル - 大豆イソフラボン
高田 吉丈, 菊池 彰夫
近畿中国四国農業研究センター / 東北農業研究センター
食品中の機能性成分分析法マニュアル集 (2010)


Soyasaponin

食品中の健康機能性成分の分析法マニュアル - 大豆サポニン
高田 吉丈
近畿中国四国農業研究センター
食品中の機能性成分分析法マニュアル集 (2010)


Alkyl (Alkenyl) Trisulfides (Partition Coefficient, log P)

Relationship Between Lipophilicity and Inhibitory Activity Against Cancer Cell Growth of Nine Kinds of Alk(en)yl Trisulfides With Different Side Chains
Yuji Iitsuka, Yuki Tanaka, Tomomi Hosono-Fukao, Takashi Hosono, Taiichiro Seki, and Toyohiko Ariga
Nihon University
Oncology Research, Vol. 19, pp. 575-582 (2010)


Isoflavones (Equol, Daizein, Dihydrodaizein)

Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella
Toshinari Maruo, Mitsuo Sakamoto, Chiaki Ito, Toshiya Toda and Yoshimi Benno
FUJICCO / RIKEN
International Journal of Systematic and Evolutionary Microbiology (2008), 58, 1221-1227


Fumonisins

ビール中カビ毒 トリコテセン系カビ毒及びフモニシン類のLC-MS/MS分析
須賀 啓子, 田村 昌義, 北川 泰, 望 月 直樹
アサヒビール
日本食品化学学会誌 Vol.14 (2) 93-98 (2007)


Catechol-O-Methyltransferase Activity (Norepinephrine, Normetanephrine)

Measurement of Catechol-O-methyltransferase Activity in the Brain of Dahl Salt-Sensitive Rats
Yoko HIRANO, Makoto TSUNODA, Tatsuo SHIMOSAWA, Toshiro FUJITA and Takashi FUNATSU
The University of Tokyo
Biol. Pharm. Bull. 30(11) 2178-2180 (2007)


Peptides (GPI Anchor of CD59)

PGAP2 Is Essential for Correct Processing and Stable Expression of GPI-anchored Proteins
Yuko Tashima, Ryo Taguchi, Chie Murata, Hisashi Ashida, Taroh Kinoshita, and Yusuke Maeda
Osaka University / The University of Tokyo
Molecular Biology of the Cell, Vol. 17, 1410-1420, March 2006


Halogenated Benzylamines

Enthalpy-entropy compensation of halogenated benzylamines in reversed-phase liquid chromatography
Masato Kazusaki and Toshikazu Yamaguchi
Dainippon Sumitomo Pharma Co., Ltd.
Chromatography, Vol.27 No.2 (2006), 57-62


GDP-Mannose Epimerase (GDP-Galactose, GDP-Glucose)

Characterization of a GDP-D-mannose 3",5"-epimerase from rice
Kentaroh Watanabe, Kiyoshi Suzuki, Shinichi Kitamura
Osaka Prefecture University
Phytochemistry, 67 (2006) 338-346


Nucleotides (ATP, ADP, AMP)

Isoleucine, a Blood Glucose-Lowering Amino Acid, Increases Glucose Uptake in Rat Skeletal Muscle in the Absence of Increases in AMP-Activated Protein Kinase Activity
Masako Doi, Ippei Yamaoka, Mitsuo Nakayama, Shinji Mochizuki, Kunio Sugahara, and Fumiaki Yoshizawa
Otsuka Pharmaceutical Factory, Inc. / Utsunomiya University
The Journal of Nutrition, Volume 135, Issue 9, Pages 2103-2108, September 2005

문의하기 애플리케이션 보기