Comparative study on incorporation of three recombinant human α-galactosidase A drugs (agalsidases) into cultured fibroblasts and organs/tissues of Fabry mice

Toru Tsukimura, Takashi Shiga, Takahiro Togawa, Hiroki Sakuraba
Molecular Genetics and Metabolism. 2024;141(3):108051
https://doi.org/10.1016/j.ymgme.2024.108051

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Profiles of Globotriaosylsphingosine Analogs and Globotriaosylceramide Isoforms Accumulated in Body Fluids from Various Phenotypic Fabry Patients

Takashi Shiga, Toru Tsukimura, Takashi Kubota, Takahiro Togawa, Kenta Saito, Hiroki Sakuraba
Internal Medicine. 2024;63(4):563-571
https://doi.org/10.2169/internalmedicine.2062-23

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Does administration of hydroxychloroquine/amiodarone affect the efficacy of enzyme replacement therapy for Fabry mice?

Toru Tsukimura, Kenta Saito, Takashi Shiga, Yuki Ogawa, Hiroki Sakuraba
Molecular Genetics and Metabolism. 2024;141(2):107947
https://doi.org/10.1016/j.ymgme.2024.107947

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Quantitation of Vaporized γ-Aminobutyric Acid in Cigarette Smoke Extract From e-Cigarettes by the Combination of HPLC-Fluorescence Detection and Derivatization

Masayuki Wada, Hiroshi Onodera, Masahiro Takada, Shingo Saruwatari, Yuki Tanaka, Kenji Saito
Journal of Separation Science. 2024;47(6):e2300891
https://doi.org/10.1002/jssc.202300891

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Determination of HPLC-ESI-MS/MS Based Phospholipids and Sphingolipids on Dried Plasma Filter Paper with Human Colorectal Cancer

Jihun Jo, Hye-Ran Yoon
Chromatographia. 2024;87:695-705
https://doi.org/10.1007/s10337-024-04353-9/

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Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-accelerated mice (SAMP8) by peripheral administration

Yumi Sasayama, Takayoshi Mamiya, Jianhua Qi, Takahiro Shibata, Koji Uchida, Toshitaka Nabeshima, Makoto Ojika
Bioorganic & Medicinal Chemistry, Volume 78, 15 January 2023, 117144

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A Single- and Multiple-Dose Pharmacokinetic Study of Oral Perampanel in Healthy Chinese Subjects

Shan Jing, Sari Shiba, Masafumi Morita, Sanae Yasuda, Yang Lin
Clinical Drug Investigation (2023) 43:155-165

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Analytical Method for Determination of Laccaic Acids in Foods with HPLC-PDA and Monitoring

Jae Wook Shin, Hyun Ju Lee, Eunjoo Lim, Jung Bok Kim
Journal of Food Hygiene and Safety Vol.38 No.5 pp.390-401, 2023
https://doi.org/10.13103/JFHS.2023.38.5.390

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In Vivo Delivery of Therapeutic Molecules by Transplantation of Genome-Edited Induced Pluripotent Stem Cells

Ittetsu Nakajima, Takahiro Tsukimura, Terumi Ono, Tomoko Shiga, Hiroshi Shitara, Tadayasu Togawa, Hitoshi Sakuraba, and Yuichiro Miyaoka
Cell Transplantation, Volume 32: 1-11, 2023

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Nonclinical safety evaluation of food colorant lac dye via systematic toxicity profiling with assessment of in vivo antigenic potential

Jin-Sung Park, Seung-Hyun Kim, Yun-Soon Kim, Euna Kwon, Hyun-Jin Lim, Kang-Min Han, Yang-Kyu Choi, Chul-Woo Jung, Byeong-Cheol Kang
Frontiers in Pharmacology, Volume 13 - 2022
https://doi.org/10.3389/fphar.2022.1020379

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Modeling of Anticancer Sulfonamide Derivatives Lipophilicity by Chemometric and Quantitative Structure-Retention Relationships Approaches

Monika Pastewska, Beata Zolnowska, Strahinja Kovacevic, Hanna Kapica, Maciej Gromelski, Filip Stolinski, Jaroslaw Slawinski, Wieslaw Sawicki and Krzesimir Ciura
Molecules 2022, 27, 3965

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Intravenous Perampanel as an Interchangeable Alternative to Oral Perampanel: A Randomized, Crossover, Phase I Pharmacokinetic and Safety Study

Ziad Hussein, Oneeb Majid, Peter Boyd, Jagadeesh Aluri, Leock Y Ngo, and Larisa Reyderman
Clinical Pharmacology in Drug Development, 2022, 11(7) 878-888

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Development of LC-MS/MS analytical methods for metalaxyl in Atractylodes macrocephala Koidzumi and Achyranthes japonica Nakai

Myung-Sub Yun, Seung-Hyun Yang, Hoon Choi
J Appl Biol Chem (2022) 65(1), 17−21
https://doi.org/10.3839/jabc.2022.003

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Comparative urinary globotriaosylceramide analysis by thin-layer chromatography-immunostaining and liquid chromatography-tandem mass spectrometry in patients with Fabry disease

Tomoko Shiga, Takahiro Tsukimura, Yurie Namai, Tadayasu Togawa, Hitoshi Sakuraba
Molecular Genetics and Metabolism Reports, Volume 29, December 2021, 100804

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Population Pharmacokinetic Analysis and Dosing Optimization Based on Unbound Daptomycin Concentration and Cystatin C in Nonobese Elderly Patients with Hypoalbuminemia and Chronic Kidney Disease

Masaru Samura, Keisuke Takada, Risako Yamamoto, Hayato Ito, Fumio Nagumo, Masaki Uchida, Takenori Kurata, Sakura Koshioka, Yuki Enoki, Kazuaki Taguchi, Ryuji Higashita, Norifumi Kunika, Koji Tanikawa & Kazuaki Matsumoto
Pharmaceutical Research, Volume 38, pages 1041-1055, (2021)

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Changes in Adrenal Androgens and Steroidogenic Enzyme Activities From Ages 2, 4, to 6 Years: A Prospective Cohort Study

Jae Hyun Kim, Young Ah Lee, Youn-Hee Lim, Kyunghoon Lee, Bung-Nyun Kim, Johanna Inhyang Kim, Yun-Chul Hong, Sei Won Yang, Junghan Song, Choong Ho Shin
The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 10, October 2020, Pages 3265-3272
https://doi.org/10.1210/clinem/dgaa498

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Curcumin Ameliorates Benzo[a]pyrene-Induced DNA Damages in Stomach Tissues of Sprague-Dawley Rats

Kyeong Seok Kim, Na Yoon Kim, Ji Yeon Son, Jae Hyeon Park, Su Hyun Lee, Hae Ri Kim, Boomin Kim, Yoon Gyoon Kim, Hye Gwang Jeong, Byung Mu Lee and Hyung Sik Kim
International Journal of Molecular Sciences, 20, 5533, 2019

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Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver

Hiroshi Iwata, Masatomo Goto, Norifumi Sakai, Hiroshi Suemizu & Hiroshi Yamazaki
Xenobiotica, 49, 11, 1311-1322, 2019

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Rapid Identification of Anthocyanin in Ficus Aurata Fruits by Liquid Chromatography-Mass Spectrometry Approach

Daimon Syukri, Ismed, Vioni Derosya, Ririn Fatma Nanda and Dosmawarni Indah Gultom
Oriental Journal of Chemistry, 35, 5, 2019

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Influence of Hydrolysis Susceptibility and Hydrophobicity of SN-38 Nano-Prodrugs on Their Anticancer Activity

Yoshitaka Koseki, Yoshikazu Ikuta, Liman Cong, Mayumi Takano-Kasuya, Hiroshi Tada, Mika Watanabe, Kohsuke Gonda, Takanori Ishida, Noriaki Ohuchi, Keita Tanita, Farsai Taemaitree, Anh Thi Ngoc Dao, Tsunenobu Onodera, Hidetoshi Oikawa, and Hitoshi Kasai
Bulletin of the Chemical Society of Japan, 92, 8, 1305-1313, 2019

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Simultaneous Assay of Fecal Short-Chain Fatty and Bile Acids and Ratio of Total Bile Acids to Butyrate in Colon Cancer

Tsuyoshi TORII, Kentaku KANEMITSU, Akeo HAGIWARA
Chromatography, 40, 49-57, 2019

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Measurement of serum steroid profiles by HPLC-tandem mass spectrometry

Dmitrii Olisov, Kyunghoon Lee, Sun-Hee Jun, Sang Hoon Song, Jae Hyun Kim, Young Ah Lee, Choong Ho Shin, Junghan Song
Journal of Chromatography B, 1117, 1, 1-9, 2019

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Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate

Tomonori Miura, Hiroshi Suemizu, Masatomo Goto, Norifumi Sakai, Hiroshi Iwata, Makiko Shimizu & Hiroshi Yamazaki
Xenobiotica, 49, 5, 513-520, 2019

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Practical one-step glucuronidation via biotransformation

Takashi Ohnuki, Masahiko, Ejiri, Masaaki Kizuka, Mie Fujiwara, Takahide Nishi
Bioorganic & Medicinal Chemistry Letters, 29, 2, 199-203, 2019

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Lycosides, unusual carotenoid-derived terpenoid glycosides from a vegetable juice, inhibit asexual reproduction of the plant pathogen Phytophthora

R.Iwai, Han ChunGuang Han ChunGuang, S.V.S.Govindam, M.Ojika
Journal of Agricultural and Food Chemistry, 2018, Vol. 66, No. 1, 163-169

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Local dermal delivery of cyclosporin A, a hydrophobic and high molecular weight drug, using dissolving microneedles

Hye-Rin Jeong, Ji-Yeon Kim, Sang-Nyun Kim, Jung-Hwan Park
European Journal of Pharmaceutics and Biopharmaceutics, 127, 237-243, 2018

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Cholesterol Unbound RORγt Protein Enables a Sensitive Inverse Agonist Screening

Ryokichi Koyama, Yasunori Fukuda, Yusuke Kamada, Hideyuki Nakagawa, Darbi Witmer, Geza Ambrus-Aikelin, Bi-Ching Sang, Masaharu Nakayama, and Hidehisa Iwata
ASSAY and Drug Development Technologies, 16, 4, 194-204, 2018

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Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies

Norie Murayama, Kanako Yajima, Mikiko Hikawa, Kanami Shimura, Yu Ishii, Masaki Takada, Yasuhiro Uno, Masahiro Utoh, Kazuhide Iwasaki, Hiroshi Yamazaki
Biopharmaceutics & drug disposition, 39, 2, 116-121, 2018

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2-S-cysteinylhydroquinone is an intermediate for the firefly luciferin biosynthesis that occurs in the pupal stage of the Japanese firefly, Luciola lateralis

Shusei Kanie, Ryosuke Nakai, Makoto Ojika, Yuichi Oba
Bioorganic Chemistry. 80, 223-229, 2018

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Identification of a freshness marker metabolite in stored soybean sprouts by comprehensive mass-spectrometric analysis of carbonyl compounds

Daimon Syukri, Manasikan Thammawong, Hushna Ara Naznin, Shinichiro Kuroki, Mizuki Tsuta, Makoto Yoshida, Kohei Nakanoa
Food Chemistry, 269, 588-594, 2018

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自動車塗装廃水からのメラミン分解菌の取得とメラミン分解方法の基礎的研究

杉山英彦, 梶谷修司, 辻　正男, 河野誉之, 林　久雄, 今枝孝夫
日本水処理生物学会誌, 54, 2, 47-54, 2018

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Pharmacokinetic and pharmacodynamic evaluation according to absorption differences in three formulations of ibuprofen

Dongseong Shin, Sook Joung Lee, Yu-Mi Ha, Young-Sim Choi, Jae-Won Kim, Se-Rin Park, and Min Kyu Park
Drug Design, Development and Therapy, 11, 135-141, 2017

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Universality of the Phytophthora mating hormones and diversity of their production profile

Tomohiko Tomura, Shylaja D. Molli, Ryo Murata and Makoto Ojika
Scientific Reports, 7, 5007, 2017

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Simultaneous Analysis of Oil-Soluble, Basic, and Acidic Illegal Dyes in Foods Using Liquid Chromatography?Diode-Array Detection

Yoko Uematsu, Toshiko Mizumachi, Kimio Monma
Journal of AOAC International, 100, 4, 1102-1109, 2017

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Determination of 3-hydroxypropylmercapturic acid in urine by three column-switching high-performance liquid chromatography with electrochemical detection using a diamond electrode

Kyohei Higashi, Mana Shibasaki, Kyoshiro Kuni, Takeshi Uemura, Masaaki Waragai, Kenichi Uemura, Kazuei Igarashi, Toshihiko Toida
Journal of Chromatography A, 1517, 79-85, 2017

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An inter-laboratory cross-validation study for the determination of perampanel in human plasma by liquid chromatography assays

Yuji Mano
Biomedical Chromatography, 30, 12, 2067-2069, 2016

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Pathogenic microorganisms, heavy metals, and antibiotic residues in seven Korean freshwater aquaculture species

Jae-Suk Choi, Sun-Mee Park, Young Hun Kim, Sang Cheol Oh, Eun Seo Lim, Yong-Ki Hong and Mi-Ryung Kim
Food Science and Biotechnology, 25, 1469-1476, 2016

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Drug Release is Determined by the Chain Length of Fatty Acid-Conjugated Anticancer Agent as One Component of Nano-Prodrug

Yoshitaka Koseki, Yoshikazu Ikuta, Takaaki Kamishima, Tsunenobu Onodera, Hidetoshi Oikawa, Hitoshi Kasai
Bulletin of the Chemical Society of Japan, 89, 5, 540-545. 2016

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In Vitro Metabolic Pathways of the New Anti-Diabetic Drug Evogliptin in Human Liver Preparations

Hyeon-Uk Jeong, Ju-Hyun Kim, Dae Young Lee, Hyun Joo Shim, Hye Suk Lee
Molecules, 20(12), 21802-21815, 2015

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Organic anion transporter 3- and organic anion transporting polypeptides 1B1- and 1B3-mediated transport of catalposide

Hyeon-Uk Jeong, Mihwa Kwon, Yongnam Lee, Ji Seok Yoo, Dae Hee Shin, Im-Sook Song, Hye Suk Lee
Drug Design, Development and Therapy, 9, 643-653. 2015

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Synthesis and Characterization of a New Hydroquinone Derivative: Disodium p-Phenylene Diisostearyl Diphosphate

Masayoshi Hisama, Sanae Matsuda, Junichi Arai, Katsunobu Masui, Haruo Yamamura
Journal of Oleo Science, 64, 9, 1033-1041, 2015

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Synthesis of deleobuvir, a potent hepatitis C virus polymerase inhibitor, and its major metabolites labeled with carbon-13 and carbon-14

Bachir Latli, Matt Hrapchak, Maxim Chevliakov, Guisheng Li, Scot Campbell, Carl A. Busacca, Chris H. Senanayake
Journal of Labelled Compounds and Radiopharmaceuticals, 58, 6, 250-260, 2015

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Quantification of serum C-peptide by isotope-dilution liquid chromatography-tandem mass spectrometry: Enhanced detection using chemical modification and immunoaffinity purification

Tomoya Kinumi, Ryoko Mizuno, Akiko Takatsu
J. Chromatography B, 953-954, 138-142, 2014

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Induction of a Hardening Phenomenon and Quantitative Changes of Ceramides in Stratum Corneum

Sook Young Park, Jin Hye Kim, Soo Ick Cho, Kyeong Il Kim, Hee Jin Cho, Chun Wook Park, Cheol Heon Lee, Hye One Kim
Ann Dermatol., 26(1), 35-42, 2014

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Indirect Quantitation of Saxitoxin by HPLC with Post-column Oxidation and Fluorometric Detection

Ryuichi WATANABE, Tomoko HARADA, Ryoji MATSUSHIMA, Hiroshi OIKAWA, Yasukatsu OSHIMA, Masaki KANENIWA, Toshiyuki SUZUKI
Analytical Sciences, 30, 9, 931-936, 2014

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Exposure evaluation of adult male Japanese smokers switched to a heated cigarette in a controlled clinical setting

Chikako Sakaguchi, Aoi Kakehi, Naoki Minami, Akira Kikuchi, Yasuyuki Futamura
Regulatory Toxicology and Pharmacology, 69, 3, 338-347, 2014

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Biosynthesis of Firefly Luciferin in Adult Lantern: Decarboxylation of L-Cysteine Is a Key Step for Benzothiazole Ring Formation in Firefly Luciferin Synthesis

Yuichi Oba, Naoki Yoshida, Shusei Kanie, Makoto Ojika, Satoshi Inouye
PLoS One, 8, 12, e84023, 2013

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Staphylococcus aureus Penicillin-Binding Protein 2 Can Use Depsi-Lipid II Derived from Vancomycin-Resistant Strains for Cell Wall Synthesis

Jun Nakamura, Hidenori Yamashiro, Hiroto Miya, Kenzo Nishiguchi, Hideki Maki, and Hirokazu Arimoto
Chemistry - A European Journal, 19, 36, 12104-12112, 2013

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Single-Dose Pharmacokinetic Properties, Bioavailability, and Tolerability of Two Lamivudine 100-mg Tablet Formulations: A Randomized Crossover Study in Healthy Chinese Male Subjects

Xiaojiao Li, Bin Liu, Yanfu Sun, Haiyan Chen, Hong Chen, Hong Zhang, Qi Zhang, Yanhua Ding
Clinical Therapeutics, 35, 10, 1546-1556, 2013

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The Blood-Brain Barrier Permeability of 18β-Glycyrrhetinic Acid, a Major Metabolite of Glycyrrhizin in Glycyrrhiza Root, a Constituent of the Traditional Japanese Medicine Yokukansan

Masahiro Tabuchi, Sachiko Imamura, Zenji Kawakami, Yasushi Ikarashi, Yoshio Kase
Cellular and Molecular Neurobiology, 32, 7, 1139-1146, 2012

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Correlations between Chemical Compositions and Retention Times of Methacrylate Random Copolymers Using LC-ESI-MS

Hirotaka Hisatomi,Yukari Nishimoto, Hideya Kawasaki, Hikaru Momose, Koichi Ute, and Ryuichi Arakawa
Mass Spectrometry, 1(2), 2012

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Universal LC-MS method for minimized carryover in a discovery bioanalytical setting

Williams JS, Donahue SH, Gao H, Brummel CL
Bioanalysis, 4(9), 1025-1037, 2012

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Application of liquid chromatography tandem mass spectrometry for the simultaneous quantification of multiple non-opioid drugs in human plasma

Kwang-Youl Kim, Ju-Hee Kang, Cheol-Woo Kim, and Moonsuk Nam
Molecular & Cellular Toxicology, 7, 2, 185-189, 2011

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Increased Expression of Hepatic Organic Cation Transporter 1 and Hepatic Distribution of Metformin in High-fat Diet-induced Obese Mice

Eun-Hee JANG, Hyoung-Kwang KIM, Chang-Shin PARK and Ju-Hee KANG
Drug Metabolism and Pharmacokinetics, 25, 4, 392-397, 2010

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Long-Chain N-Vanillyl-acylamides from Capsicum Oleoresin

Kenji Kobata, Kazumi Saito, Hitomi Tate, Aki Nashimoto, Hiromi Okuda, Ikue Takemura, Ken Miyakawa, Masayoshi Takahashi, Kazuo Iwai and Tatsuo Watanabe
J. Agric. Food Chem., 58 (6), 3627-3631, 2010

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Integration of photocatalysis and membrane distillation for removal of mono- and poly-azo dyes from water

Sylwia Mozia, Antoni W. Morawski, Masahiro Toyoda, Tomoki Tsumura
Desalination, 250, 2, 666-672, 2010

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Chemiluminescence detection in liquid chromatography: Applications to clinical, pharmaceutical, environmental and food analysis -A review

Laura Gamiz-Gracia, Ana M.Garcia-Campana, Jose F.Huertas-Perez, Francisco J.Lara
Analytica Chimica Acta, 640, 1-2, 7-28, 2009

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Evaluation of the antioxidant activity of the fruiting body of Phellinus linteus using the on-line HPLC-DPPH method

Young Eun Jeon, Yeon Sil Lee, Soon Sung Lim, Sun-Ju Kim, Sang Hoon Jung, Young-Soo Bae, Jae-Seon Yi & Il-Jun Kang
Journal of the Korean Society for Applied Biological Chemistry, 52, 472-479, 2009

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Effect of process parameters on photodegradation of Acid Yellow 36 in a hybrid photocatalysis-membrane distillation system

Sylwia Mozia, Antoni W. Morawski, Masahiro Toyoda, Tomoki Tsumura
Chemical Engineering Journal, 150, 1, 152-159, 2009

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Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys

Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume, and Koichiro Fukuzaki
DRUG METABOLISM AND DISPOSITION, 37, 1, 122-128, 2009

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Effectiveness of photodecomposition of an azo dye on a novel anatase-phase TiO2 and two commercial photocatalysts in a photocatalytic membrane reactor (PMR)

Sylwia Mozia, Antoni W. Morawski, Masahiro Toyoda, Michio Inagaki
Separation and Purification Technology, 63, 2, 386-391, 2008

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Isoflavone aglycones production from isoflavone glycosides by display of β-glucosidase from Aspergillus oryzae on yeast cell surface

Masahiko Kaya, Junji Ito, Atsushi Kotaka, Kengo Matsumura, Hiroki Bando, Hiroshi Sahara, Chiaki Ogino, Seiji Shibasaki, Kouichi Kuroda, Mitsuyoshi Ueda, Akihiko Kondo, Yoji Hata
Applied Microbiology and Biotechnology, 79, 1, 51-60, 2008

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Rate-Limiting Steps of Oral Absorption for Poorly Water-Soluble Drugs in Dogs; Prediction from a Miniscale Dissolution Test and a Physiologically-Based Computer Simulation

Ryusuke Takano, Kentaro Furumoto, Koji Shiraki, Noriyuki Takata, Yoshiki Hayashi, Yoshinori Aso, Shinji Yamashita
Pharmaceutical Research, 25, 10, 2334-2344, 2008

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Determination of testosterone concentrations in rat plasma using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry combined with ethyl oxime and acetyl ester derivatization

Makoto Niwa, Noriko Watanabe, Hisashi Ochiai, Kouwa Yamashita
J. Chromatography B, 824, 1-2, 258-266, 2005